Remodelin hydrobromide ( Remodelin HBr | Remodelin Hydrobromide )

产品货号. M12394 CAS No. 1622921-15-6

乙酰转移酶蛋白 NAT10 的有效抑制剂，可乙酰化组蛋白和微管。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥421	有现货
10MG	￥640	有现货
25MG	￥1199	有现货
50MG	￥2122	有现货
100MG	￥3175	有现货
500MG	￥7177	有现货
1G	获取报价	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Remodelin hydrobromide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

乙酰转移酶蛋白 NAT10 的有效抑制剂，可乙酰化组蛋白和微管。
产品描述

A potent inhibitor of the acetyl-transferase protein NAT10 that acetylates both histones and microtubules; significantly reduces the prevalence of misshapen nuclei in HGPS cells, prevents FTI-induced nuclear shape defects in normal fibroblasts and U2OS cells; does not affect Golgi apparatus integrity or tubulin polymer assembly, and does not cause cells to accumulate in mitosis.
体外实验

Cell Proliferation Assay Cell Line:Prostate cancer cell lines VCaP, PC3, and DU145 Concentration:0,10,20,40 μM Incubation Time:1,2,7 days Result:Inhibited NAT10 and suppressed the growth of both AR-positive and AR-negative prostate cancer cells. Displayed significantly decreased cell proliferation activity over time, compared to the control group.Decreased colony formation ability with a dose-dependent manner. Immunofluorescence Cell Line:Prostate cancer cell lines VCaP, PC3, and DU145 Concentration:20 μM Incubation Time:24 h Result:Showed a significant decrease in both the positive labeling rate and the fluorescence intensity compared to the control group. Significantly reduced both the staining foci of IdU and the staining foci of CldU compared to control group. Western Blot Analysis Cell Line:Skin fibroblasts from LmnaG609G/G609G and wildtype (WT) littermates Concentration:1 μM Incubation Time:7 days Result:Decreased the higher level of the DNA double-strand break (DSB) marker gamma H2AX (γH2AX, Ser-139 phosphorylated histone H2AX).
体内实验

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同义词

Remodelin HBr | Remodelin Hydrobromide
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

acetyl-transferaseNAT10
研究领域

Other Indications
适应症

——

化学信息

CAS Number

1622921-15-6
分子量

363.2754
分子式

C15H15BrN4S
纯度

>98% (HPLC)
溶解度

DMSO: ≥ 44 mg/mL
SMILES

N#CC1=CC=C(C2=CSC(N/N=C3CCCC/3)=N2)C=C1.[H]Br
化学全称

Benzonitrile, 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-, hydrobromide (1:1)

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Larrieu D, et al. Science. 2014 May 2;344(6183):527-32. 2. Mathieu J, et al. Cell Stem Cell. 2016 Jul 7;19(1):3-4. 3. Cobb AM, et al. Aging Cell. 2016 Jul 27. doi: 10.1111/acel.12506.

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